Moses ben-Maimon, Maimonides (1135-1204) wrote to Rabbi Jacob Alfajumi: Likewise said Isaiah that He (Messiah) would appear without acknowledging a father or mother: “He grew up before Him as a tender plant and as a root out of a dry ground” etc. (Isaiah 53:2).
Talmud, Sanhedrin 98b: Rav said: The world was created only on David’s account. Samuel said: On Moses account; R. Johanan said: For the sake of the Messiah. What is His [the Messiah’s] name? - The Rabbis said: His name is “the leper scholar,” as it is written, Surely He hath borne our griefs, and carried our sorrows: yet we did esteem Him a leper, smitten of G-d, and afflicted.
Talmud, Sanhedrin 98b: Messiah... what is His name? The Rabbis say, “the leprous one”; those of the house of the Rabbi say: “Cholaja” (the sickly), for it says, “Surely He has borne our sicknesses” etc. (Isaiah 53:4).
Targum Jonathan (4th Century) gives the introduction on Isaiah 52:13: “Behold, My servant the Messiah...”